Download MendeleyCrystal structure of the human METTL3-METTL14 complex with compound T180
Bedi, R.K., Huang, D., Caflisch, A.To be published.
7O2X
Crystal structure of the human METTL3-METTL14 complex with compound T180
- PDB DOI: https://doi.org/10.2210/pdb7O2X/pdb
- Classification: TRANSFERASE
- Organism(s): Homo sapiens
- Expression System: Spodoptera frugiperda
- Mutation(s): No
- Deposited: 2021-03-31 Released: 2021-04-07
- Funding Organization(s): Swiss National Science Foundation
Experimental Data Snapshot
- Method: X-RAY DIFFRACTION
- Resolution: 2.80 Å
- R-Value Free: 0.274
- R-Value Work: 0.208
- R-Value Observed: 0.211
Starting Model: experimental
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This is version 1.1 of the entry. See complete history.
Literature
To be published.
Macromolecules
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 1 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| N6-adenosine-methyltransferase catalytic subunit | 246 | Homo sapiens | Mutation(s): 0 Gene Names: METTL3, MTA70 EC: 2.1.1.348 |  | |
UniProt & NIH Common Fund Data Resources | |||||
Find proteins for Q86U44 (Homo sapiens) Explore Q86U44 Go to UniProtKB: Q86U44 | |||||
PHAROS: Q86U44 GTEx: ENSG00000165819 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Group | Q86U44 | ||||
Sequence AnnotationsExpand | |||||
| |||||
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 2 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| N6-adenosine-methyltransferase non-catalytic subunit | 290 | Homo sapiens | Mutation(s): 0 Gene Names: METTL14, KIAA1627 |  | |
UniProt & NIH Common Fund Data Resources | |||||
Find proteins for Q9HCE5 (Homo sapiens) Explore Q9HCE5 Go to UniProtKB: Q9HCE5 | |||||
PHAROS: Q9HCE5 GTEx: ENSG00000145388 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Group | Q9HCE5 | ||||
Sequence AnnotationsExpand | |||||
| |||||
Small Molecules
| Ligands 2 Unique | |||||
|---|---|---|---|---|---|
| ID | Chains | Name / Formula / InChI Key | 2D Diagram | 3D Interactions | |
| V0B (Subject of Investigation/LOI) Query on V0B | C [auth A] | N-[(6-methylimidazo[1,2-a]pyridin-2-yl)methyl]-4-oxidanylidene-pyrido[1,2-a]pyrimidine-2-carboxamide C18 H15 N5 O2 HGTYDECGVDYGCR-UHFFFAOYSA-N |  | ||
| ACT Query on ACT | D [auth B] | ACETATE ION C2 H3 O2 QTBSBXVTEAMEQO-UHFFFAOYSA-M |  | ||
Experimental Data & Validation
Experimental Data
- Method: X-RAY DIFFRACTION
- Resolution: 2.80 Å
- R-Value Free: 0.274
- R-Value Work: 0.208
- R-Value Observed: 0.211
- Space Group: P 32 2 1
Unit Cell:
| Length ( Å ) | Angle ( ˚ ) |
|---|---|
| a = 63.95 | α = 90 |
| b = 63.95 | β = 90 |
| c = 225.72 | γ = 120 |
| Software Name | Purpose |
|---|---|
| XDS | data reduction |
| XSCALE | data scaling |
| PHASER | phasing |
| PHENIX | refinement |
Entry History & Funding Information
Deposition Data
- Released Date: 2021-04-07 Deposition Author(s): Bedi, R.K., Huang, D., Caflisch, A.
| Funding Organization | Location | Grant Number |
|---|---|---|
| Swiss National Science Foundation | Switzerland | 310030B_189363 |
Revision History (Full details and data files)
- Version 1.0: 2021-04-07
Type: Initial release - Version 1.1: 2024-01-31
Changes: Data collection, Database references, Refinement description
