Browse and Explore ECOD Annotations

02/01

ECOD (Evolutionary Classification of Protein Domains) annotations have been mapped to PDB structures.

The Evolutionary Classification Of protein Domains (ECOD) database classifies domains according to evolutionary relationships: (A) architecture, (X) possible homology, (H) homology, (T) topology, (F): Family.

Compared with other classification databases (e.g., SCOP, CATH) ECOD emphasizes distant evolutionary relationships.

These ECOD annotations have been mapped to PDB structures.

Explore ECOD classifications for a particular structure through the Annotations tab and the Sequence tab (Protein Feature View) for 7ad1, a trimeric spike protein of SARS-CoV-2).

Use the ECOD Browser at RCSB.org to find proteins with a particular classification.

For more information on ECOD, see

ECOD: An evolutionary classification of protein domains
H. Cheng, R. D. Schaeffer, Y. Liao, L. N. Kinch, J. Pei, S. Shi, B. H. Kim, N. V. Grishin.
(2014) PLoS Comput Biol 10(12): e1003926 doi: 10.1371/journal.pcbi.1003926

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