News

Automatically Evaluate Quaternary Structure with EPPIC

06/19

EPPIC (Evolutionary Protein-Protein Interface Classifier) provides value-added information about biological assemblies in the PDB. This web server classifies interfaces present in protein crystals to distinguish biological interfaces from crystal contacts. The latest version of EPPIC (v3) now enumerates all possible symmetric assemblies with a prediction of the most likely assembly based on probabilistic scores from pairwise evolutionary scoring. EPPIC is now fully hosted and supported at RCSB PDB.

A detailed description was recently published:

  • S Bliven, A Lafita, A Parker, G Capitani, JM Duarte (2018) Automated evaluation of quaternary structures from protein crystals. PLoS Comput Biol 14(4): e1006104. doi: 10.1371/journal.pcbi.1006104

EPPIC was also highlighted in the PLOS BIOLOGUE.

The EPPIC project was initiated by Guido Capitani at the Paul Scherrer Institut. Guido sadly passed away in 2017. He was a good friend and colleague and will be missed.

RCSB PDB News ImageEPPIC assembly graph corresponding to the D3 symmetric assembly of PDB structure 4ht5. Nodes are protein molecules and edges interfaces between them. Different edge colors represent distinct modes of binding.

News Index