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PDB50 at ACS August 25
06/22
Celebrate PDB50 at the Fall 2021 ACS Meeting with a session on Understanding Enzyme Function in 3D: Celebrating 50 Years of the Protein Data Bank.
All times shown are are listed in Eastern Daylight Time (EDT) on Wednesday August 25, 2021.
2:00 Introductory Remarks
2:05 The winding road from G-quadruplexes to telomerase, Juli Feigon (UCLA)
2:45 Enhanced exploration of small-molecule ligands bound to proteins and nucleic acids, Stephen K. Burley (Rutgers University and UCSD)
3:10 Mechanistic insights into the cleavage and polyadenylation machinery, Lori Passmore (University of Cambridge)
3:35 Vive la difference! The synergies and differences between the PDB and the CSD, Jason Cole (CCDC)
4:00 Break
4:30 Beyond static snapshots of protein structure: The role of dynamics in function, George Phillips Jr. (Rice University)
5:10 Evolution of the SARS-CoV-2 proteome in three dimensions (3D) during the COVID-19 pandemic, Sagar Khare (Rutgers)
5:35 Cracking the phosphatase code: Holoenzyme formation, regulatory protein binding and susbtrate dephosphorylation by the phosphoprotein phosphatase family, Rebecca Page (Brown)
6:00 Small molecules targeting COVID-19 in an evolving landscape of publishing and peer review, James Fraser (UCSF)
6:30 Break
7:00 Watching metalloenzymes at work, Amie Boal (Penn State)
7:25 Time travel to the past and future – evolution of energy landscapes for enzymes catalysis, Dorothee Kern (Brandeis)
7:50 Structure, mechanism, and inhibition of class IIb histone deacetylases, David Christianson (Harvard)
8:15 Truth sometimes triumphs: The history of structural enzymology, Gregory Petsko (Brandeis)
8:55 Closing Remarks
Visit ACS for registration information.
This symposium was organized by Carmen Nitsche (CCDC), and Steven C. Almo (Albert Einstein College of Medicine), and Stephen K. Burley (RCSB PDB).