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COVID-19/SARS-CoV-2 Resources

03/25

RCSB.org/covid19:
PDB Structures (as of November 6, 2024)

Access all SARS-CoV-2 PDB structures

Adapted from Architecture of the SARS-CoV-2 genome and proteome in Evolution of the SARS-CoV-2 proteome in three dimensions (3D) during the first 6 months of the COVID-19 pandemic <I>Proteins: Structure, Function, and Bioinformatics</I> (2022) 90: 1054-1080; doi: <a href="https://doi.org/10.1002/prot.26250">10.1002/prot.26250</a>Adapted from Architecture of the SARS-CoV-2 genome and proteome in Evolution of the SARS-CoV-2 proteome in three dimensions (3D) during the first 6 months of the COVID-19 pandemic Proteins: Structure, Function, and Bioinformatics (2022) 90: 1054-1080; doi: 10.1002/prot.26250

Scientific Publications

  • Genetic and Structural Analysis of SARS-CoV-2 Spike Protein for Universal Epitope Selection (2022) Molecular Biology and Evolution 39: msac091 doi: 10.1093/molbev/msac091
  • Structural models of SARS-CoV-2 Omicron variant in complex with ACE2 receptor or antibodies suggest altered binding interfaces (2021) bioRxiv doi: 10.1101/2021.12.12.472313
  • Design and proof of concept for targeted phage-based COVID-19 vaccination strategies with a streamlined cold-free supply chain (2021) PNAS 118: e21057391181 doi: 10.1073/pnas.2105739118
  • Structure-enabled Design of mRNA Vaccines (2021) Structure 10.1016/j.str.2021.10.008
  • Architecture of the SARS-CoV-2 genome and proteome (2021) PROTEINS doi: 10.1002/prot.26250

PDB-101 Educational Resources and Images (all free for use)

<I>SARS-CoV-2 mRNA Vaccine</I>, 2020<BR>
David S. Goodsell, RCSB PDB<BR>
doi: <a href="http://doi.org/10.2210/rcsb_pdb/goodsell-gallery-027">10.2210/rcsb_pdb/goodsell-gallery-027</a>SARS-CoV-2 mRNA Vaccine, 2020
David S. Goodsell, RCSB PDB
doi: 10.2210/rcsb_pdb/goodsell-gallery-027
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SARS-CoV-2 Fusion, 2020
David S. Goodsell, RCSB PDB doi: 10.2210/rcsb_pdb/goodsell-gallery-026

Respiratory Droplet, 2020
David S. Goodsell, RCSB PDB doi: 10.2210/rcsb_pdb/goodsell-gallery-024

SARS-CoV-2 and Neutralizing Antibodies, 2020
David S. Goodsell, RCSB PDB doi: 10.2210/rcsb_pdb/goodsell-gallery-025

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Video: Fighting Coronavirus with Soap

Video: Watch at the molecular level how soap breaks up coronavirus.Video: Watch at the molecular level how soap breaks up coronavirus.
Animated GIFAnimated GIF
Video still images for downloadVideo still images for download

Images

<I>Coronavirus</I> Credit: Maria Voigt/RCSB PDBCoronavirus Credit: Maria Voigt/RCSB PDB
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<a href="https://www.rcsb.org/structure/6LU7">PDB structure 6LU7</a> of SARS-CoV-2 main protease<BR>
<a href="https://youtu.be/Bw51W5Y6Qdo"><B>Video</B></a><P>

Main protease protein with inhibitor N3 (white stick representation) covalently bound to residue cysteine 145 in the protease active site. Display shows secondary structure (helices in magenta, strands in cyan, loops in yellow). Adjacent active site residue histidine 41 is also shown.PDB structure 6LU7 of SARS-CoV-2 main protease
Video

Main protease protein with inhibitor N3 (white stick representation) covalently bound to residue cysteine 145 in the protease active site. Display shows secondary structure (helices in magenta, strands in cyan, loops in yellow). Adjacent active site residue histidine 41 is also shown.

Structural similarity of the SARS-CoV-2  main protease (<a href="https://www.rcsb.org/structure/6LU7">PDB structure 6lu7</a>) and the SARS coronavirus main protease (<a href="https://www.rcsb.org/structure/1q2w">PDB structure 1q2w</a> in green)<BR>
<a href="https://youtu.be/APCadT6ynyI"><B>Video</B></a>Structural similarity of the SARS-CoV-2 main protease (PDB structure 6lu7) and the SARS coronavirus main protease (PDB structure 1q2w in green)
Video
<a href="https://www.rcsb.org/structure/6LU7">PDB structure 6LU7</a> of SARS-CoV-2 main protease<BR>
<a href="https://youtu.be/4aVLltbDCKc"><B>Video</B></a><P>

Shown in a surface representation, with the two halves of the dimer in yellow and blue.PDB structure 6LU7 of SARS-CoV-2 main protease
Video

Shown in a surface representation, with the two halves of the dimer in yellow and blue.

NJTV News talks with Rutgers University researchers Stephen Burley and Brian Hudson at the Protein Data Bank about finding the key to fighting COVID-19.NJTV News talks with Rutgers University researchers Stephen Burley and Brian Hudson at the Protein Data Bank about finding the key to fighting COVID-19.
Coronavirus main protease virtual meeting background for download;
<a href="https://www.rcsb.org/structure/6LU7">based on PDB structure 6lu7</a><BR>
<a href="https://pdb101.rcsb.org/news/2020#5e8c749e2d410731e9944f6f">Other backgrounds are available for download from PDB-101</a>Coronavirus main protease virtual meeting background for download; based on PDB structure 6lu7
Other backgrounds are available for download from PDB-101

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